Benefits of natural ceramides in the Rosette AK Series

The role of ceramide

The surface of the skin has a protein layer called the stratum corneum. The spaces between cells in the stratum corneum contain a lipid called ceramide. Ceramide is an intercellular lipid that is created during the process of cell turnover, and contains about 30% moisture. It acts as the glue that holds cells together. When the skin is rich in ceramide, the stratum corneum stays moist for hydrated, dewy skin.

Atopic dermatitis, on the other hand, is known to involve extreme ceramide deficiency. We also lose ceramide as we age, causing moisture to readily evaporate from the surface of the skin during the colder months when we don’t sweat.

Ceramide keeps the outer layers of skin healthy and serves a so-called barrier function. When the epidermis is healthy, it locks in moisture and keeps antigens (allergy-causing agents like mites and dust) from infiltrating the skin. It also protects against more general environmental irritants. However, because people with atopic dermatitis lack sufficient ceramide, the barrier function is weakened. Moisture readily escapes from within the skin, drying it out and allowing antigens to enter. Once these irritants have penetrated the skin, they trigger an allergic reaction that results in various forms of inflammation.

Atopic dermatitis is also referred to as “extremely dry skin”. For this reason, in addition to pharmaceutical treatments to inhibit skin inflammation, it is important that patients follow a skincare regimen that focuses on replenishing the ceramides needed to alleviate dry skin and enhance barrier function.

Healthy skin
Dry, inflamed skin resulting from atopic dermatitis

What is the natural ceramide in the Rosette AK Series?

To ensure that our products are safe to use even by patients struggling with atopic dermatitis, the Rosette AK Series contains horse sphingolipid, which is a natural ceramide extracted from fresh spinal marrow of healthy horses. This natural ceramide contains over 70% galactosylceramide as well as an excellent balance of sphingomyelin (sphingoline lipid), phosphatidylethanolamine (sphingoline lipid), lecithin (glycerin lipid), cholesterol, and other nutrients to enhance skin’s barrier function and help it retain moisture.

Benefits of natural ceramides in the Rosette AK Series

※Source: Rosette R&D

The main ingredient in natural ceramide, galactosylceramide, activates beta-glucocerebrosidase.

Galactosylceramide is a sphingoglucolipid that is very high in the skin compared with other organs. This lipid has been reported to specifically activate beta-glucocerebrosi­dase.

  • Galactosylceramide is topically applied to the skin.
  • Beta-glucocerebrosidase is specifically activated in the skin.
  • The metabolic activity of ceramide is triggered by the skin's cerebroside.
  • A wide range of ceramides originating in the body are generated in the skin, and boost the generation of lamellar structures.

Galactosylceramide reconstructs the lamellar structure of intercellular lipids.

Model of dry skin (untreated)
Example using emulsion containing 0.3% cerebroslde
SC: Stratum corneum E: Epithelium D: Dermis

The application of a cerebroside emulsion to dry skin reconstructs the lamellar structure of the stratum corneum. (The emulsion was applied twice a day for two days. The above staining was confirmed by Baker staining.)

The Rosette AK Series products construct the lamellar structures in the intercellular lipids that support the barrier function of the epider mis, retaining water in the skin and preventing excessive water loss.