Atopic dermatitis and skincare


  1. Weidinger S, Novak N. Seminar: Atopic dermatitis. The Lancet. Retrieved online. September 14, 2015
  2. Lyons JJ, Milner JD, Stone KD. Atopic dermatitis in children: Clinical features, pathophysiology and treatment. Immunology and Allergy Clinics of North America 35:161-183, 2014
  3. Katayama I. Etiology and pathology of atopic dermatitis in adults. MB Derma 31:9-15, 2000 [In Japanese]
  4. Mukai H. clinical features of adult patients with atopic dermatitis. MB Derma 1:1-7, 2000 [In Japanese]
  5. Schmitt J, Buske-Kirschbaum A, Roessner C. Is atopic disease a risk for attention-deficit/hyperactivity disorder? A systematic review. Allergy 65:1506-1524, 2010
  6. Saeki H. General information on atopic dermatitis guidelines. Journal of Clinical and Experimental Medicine. 256: 43-48, 2016 [In Japanese]
  7. Oranje AP, Glazenburg EJ, Wolkerstorfer A, Waard-van der Spek FB. Practical issues on interpretation of scoring atopic dermatitis: the SCORAD index, objective SCORAD and the three-item severity score. The British Journal of Dermatology 157:645-648, 2007
  8. Hanifin JM, Thurston M, Omoto M, Cherill R, et al. The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. Experimental Dermatology 10:11-18, 2001
  9. Nakamura K. Experimental data on atopic dermatitis characteristics: Spotlight on TARC. MB Derma 224:65-69, 2014 [In Japanese]
  10. Tanaka A. Epidemiology of atopic dermatitis. Journal of Clinical and Experimental Medicine. 256: 5-9, 2016 [In Japanese]
  11. Strachan DP. Hay fever, hygiene, and household size. BMJ 299:1259-1260, 1989
  12. Lack G. Epidemiologic risks for food allergy. Journal of Allergy and Clinical Immunology 121:1331-1336, 2008
  13. Lau S, IIIi S, Platts-Mills TAE, Riposo D et al. Longitudinal study on the relationship between cat allergen and endotoxin exposure, sensitization, cat-specific IgG and development of asthma in childhood: Report on the German Multicentre Allergy Study (MAS 90). Allergy 60:766-773, 2005
  14. Palmer CAN, Irvine AD, Terron-Kwiatkowski A, Zhao Y et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nature Genetics 38:441-446, 2006
  15. Jarzab J, Filipowska B, Zebracka J, Kowalska M et al. Locus 1q21 gene expression changes in atopic dermatitis skin lesions: Deregulation of small protein-rich region 1A. International Archives of Allergy and Immunology 151:28-37, 2010
  16. Yamaguchi H, Kabashima-Kubo R, Bito T, Sakabe J et al. High frequencies of positive nickel/cobalt patch tests and high sweat nickel concentration in patients with intrinsic atopic dermatitis. Journal of Dermatological Science 72:240-245, 2013
  17. Greer FR, Sicherer SH, Burks AW, the Committee and Section on Allergy and Immunology. Effects of early nutritional interventions on the development of atopic disease in infants and children: The role of maternal dietary restriction, breastfeeding, timing of introduction of complementary foods, and hydrolyzed formulas. Pediatrics 121:183-191, 2008
  18. Lack G. Update on risk factors for food allergy. Journal of Allergy and Clinical Immunology 129:1187-1197, 2012
  19. Komatsu N, Takata M, Otsuki N, Ohka R et al. Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides. Journal of Investigative Dermatology 118:436-443, 2002
  20. Kim EB, Leung DYM, Bogniewicz M, Howell MD. Loricrin and involicrin expression is down-regulated by Th2 cytokines through STAT-6. Clinical Immunology 126:332-337, 2008
  21. Imokawa G, Abe A, Jin K, Higaki Y, et al. Decreased level of ceramides in stratum corneum of atopic dermatitis: An etiologic factor in atopic dry skin? Journal of Investigative Dermatology 96:523-526, 1991
  22. Strid J, Hourihane J, Kimber I, Callard R, Strobel S. Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response. European Journal of Immunology 34:2100-2109, 2004
  23. Callard R, Harper JI. The skin barrier, atopic dermatitis and allergy: a role for Langerhans cells? Trends in Immunology 28:294-298, 2007
  24. Yoshida K, Kubo A, Fujita H, Yokouchi M, et al. Distinct behavior of human Langerhans cells and inflammatory dendritic epidermal cells at tight junctions in patients with atopic dermatitis. Journal of Allergy and Clinical Immunology 134:856-864, 2014
  25. Imokawa G. Autocrine and paracrine regulation of melanocytes in human skin and in pigmentary disorders. Pigment & Melanoma Cell Research 17:96-110, 2004
  26. Auriemma M, Brzoska T, Klenner L, Kupas V, et al. α-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliolate ongoing skin inflammation Journal of Investigative Dermatology 132:1814-1824, 2012
  27. Takasu E. Dictionary of Skincare Cosmetics. The Society of Cosmetic Chemists of Japan, ed. Maruzen p. 542-544, 2003 [In Japanese]
  28. Horikawa T, Takashima T, Harada S, Chihara T, Ishihashi M. Experiences with topical preparations containing glycoceramides to treat dry skin associated with atopic dermatitis. Hifu 40: 415-419, 1998 [In Japanese]
  29. Janssens M, von Smeden J, Gooris GS, Bras W, et al. Increase in short-chain ceramides correlates with an alteree lipid organization and decreased barrier function in atopic eczema patients. Journal of Lipid Research 53:2755-2766, 2012
  30. Otsuka A, Doi H, Egawa G, Maekawa A Possible new therapeutic strategy to regulate atopic dermatitis through upregulating filaggrin expression. Journal of Allergy and Clinical Immunology 133:139-146, 2014

Dr. Masamitsu Ichihashi

Professor Emeritus, Kobe University

Dr. Ichihashi completed his doctoral program at the Kobe University Graduate School of Medicine. He specializes in dermatology, with a particular interest in researching how UV rays affect the skin over many years of exposure. He has also trained outside of Japan in dermatology and dermatological treatments.